Programmed Cell Death and Inflammation

CHEN Meng^1,2,3, DAI Haiming^1,2*

(¹Center of Pathology and Laboratory Medicine, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China; ²Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health & Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; ³University of Science and Technology of China, Hefei 230026, China)

Abstract:

Cell death is a common biological process that plays an important role in the growth and development of the body. Moreover, cell death is related to the development of many diseases. Inflammation is an immune defense response to stimuli of injury factors. Appropriate inflammation can stimulate and improve the body’s immunity. However, excessive inflammation will cause continuous damage to the body, even life-threatening. Traditionally, the cell death that causes inflammation is necrosis. Recently, it has been found that a variety of programmed cell death, including apoptosis, are related to the development of inflammation to a certain extent. This review summarizes the recent progress in the understanding of molecular mechanisms of different programmed cell death and their roles in inflammation, which aims to provide ideas for the research of related scientific issues.

CSTR: 32200.14.cjcb.2020.12.0012