Research Progress on the Role and Mechanism of AMPK Signaling Pathway in Primordial Follicular Activation

CHEN Sirun¹, LI Zimei¹, DONG Yanpeng¹, WANG Dingyue², WU De¹, XU Shengyu^1*

(¹Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Resistance Nutrition, Ministry of Education, Key Laboratory of Animal Resistance Nutrition and Feed, Ministry of Agriculture and Rural Affairs, Sichuan Key Laboratory of Animal Resistance Nutrition, Chengdu 611130, China; ²Sichuan Rota Bioengineering Co., Ltd, Chengdu 610000, China)

Abstract:

The activation and development of primordial follicles is the beginning of reproductive function in female animals. Primordial follicles are transformed into primary follicles and their further development is affected by various factors and multiple signaling pathways. Studies have shown that AMPK (AMP-activated protein kinase) is a key regulator of follicular development, and AMPK can regulate the dormancy and activation of primitive follicles through the mTOR (mammalian target of rapamycin) and Hippo signaling pathways. This paper reviews the role of AMPK in follicular development and its role in mediating the mTOR and Hippo signaling pathways in the regulation of primordial follicular dormancy or activation, in order to provide theoretical support for better solving the problems of reproduction barriers and low productivity in livestock and poultry production.

CSTR: 32200.14.cjcb.2020.12.0011