Deubiquitinases and Stem Cell Identity Regulation
WU Ying, CUI Chunping*, ZHANG Lingqiang*
ESCs (embryonic stem cells) and iPSCs (induced pluripotent stem cells) are the class of cell lines capable of self-renewal and multi-lineage differentiation. Almost all stem cells possess these two characteristics. This characteristic of stem cells is controlled and regulated by many factors, such as transcription factor regulation at the level of gene expression, mRNA alternative splicing regulation, protein post-translational modification, etc. Given UPS (ubiquitin proteasome system), which is a major machinery as a part of the protein posttranslational modifications, has played great roles in the regulation of protein dynamics. There is no doubt UPS plays a key role in regulating the self-renewal, reproduction and differentiation of stem cells. Among the three kinds of enzymes contained in the UPS, the E3 ligases and deubiquitinases are the most researched and highly focused. Here this study concluded the important cellular roles of ubiquitin dynamics in the regulating of stem cell characteristics, focusing on the summary and induction of the role of DUBs (deubiquitinates) in the control of stem cell fate to fully uncover the contribution of ubiquitin dynamics to stem cell self-renewal and differentiation.
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