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Molecular Mechanisms Regulating the Differentiation of Embryonic Stem Cells into Endothelial Cells
Zhen Zhong, Hou-Yan Song*
The Key Laboratory of Molecular Medicine, Ministry of Education of China, Fudan University, Shanghai 200032, China
Abstract: Embryonic stem cells (ES cells) are pluripotent cells capable of differentiating into almost all the cell types under different inductive conditions. Multiple signaling pathways participate in regulating the differentiation process. We reviewed the inductive conditions and molecular mechanisms regulating the differentiation of ES cells into endothelial cells and elucidated the molecular markers in different developmental stages of endothelial progenitors based on the current research results. Furthermore， the application perspective of ES cells in regenerative medicine is discussed.
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