Research Progress on the Mechanism of Autophagy Affecting Ovarian Cancer Cell Dormancy

Dormancy is widespread in mammalian cells, and is a stable and active state of inhibition of cells. The cellular metabolic activity in the dormant state is reduced, and transcription and translation are inhibited. Tumor suppressor gene expression is increased, while DNA damage is reduced. There are two stages of G₀ and G_Alert, and chemical drugs and inflammation may affect cell dormancy. In normal stem cells, dormancy helps maintain the dynamic balance of tissues and has a certain protective effect on the body. In tumors, dormancy can help cells escape immune surveillance, adapt to the environment, resist drugs, restore malignant proliferation, and prepare for tumor recurrence. Chemotherapy resistance and tumor recurrence are important reasons for the extremely poor prognosis of ovarian cancer. In recent years, studies have found that dormancy is closely related to drug resistance and recurrence of ovarian cancer. This article aims to explore the dormancy characteristics of ovarian cancer cells. Starting from autophagy, this article links the relationship among tumor angiogenesis, cell cycle and drug resistance, providing new ideas for the research of ovarian cancer recurrence, metastasis, treatment and prevention.

CSTR: 32200.14.cjcb.2020.12.0007