Regulation and Mechanism of SIRT1 on Oxidative Stress in Alzheimer’s Disease

SIRT1, a member of the silencing information regulator family, has deacetylase activity and plays an important protective role in Alzheimer’s disease. Oxidative stress is one of the pathogenesis mechanisms of Alzheimer’s disease. Current studies have found that SIRT1 can affect ROS production, antioxidant enzyme activity and neuron death through Aβ, PGC1-α, FOXO3a, Nrf2, and p53, thus regulating brain oxidative stress injury, but its mechanism still needs to be clarified. In this paper, the latest research progress at home and abroad is reviewed to further explore the regulation mechanism of SIRT1 on oxidative stress in Alzheimer’s disease, which will provide the basis and direction for SIRT1 as a target for the treatment of Alzheimer’s disease. 

CSTR: 32200.14.cjcb.2020.11.0015