Research Progress on Obesity-Related Adipose Tissue Microenvironment and the Characteristics of Adipose Stem Cells
HAN Xueya, ZHANG Haiyan*
Obesity is one of the key factors causing cardiovascular, cerebrovascular and metabolic diseases. The pathological basis of obesity-related diseases is the change of microenvironment caused by obesity, such as inflammatory cell infiltration, the increase of inflammatory factors secreted by inflammatory cells, and extracellular matrix. Recent studies show that the obesity related-adipose tissue microenvironment affects the characteristics of ASCs (adipose stem cells) which involved in the maintenance of adipose tissue structure and function homeostasis, such as the ability of stemness maintenance, differentiation potential and energy metabolism. In order to elucidate the mechanism of development of obesity, this review shows the research progress of obesity, microenvironment of adipose tissue, and the characteristics changes of ASCs.
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