The Ubiquitin-Like Modification of Neddylation Associated With Tumorigenesis and Therapies
ZHUANG Weihao, HUANG Mengyuan, NI Xinxin, OU Wenbin*
Ubiquitin-like modification neddylation is a post-translational modification of proteins similar to ubiquitination. This process binds the tag molecule NEDD8 to the target protein through a series of cascade reactions, thereby affecting the structure and function of the modified protein. Most modified substrates by neddylation, including the Cullin family members, are also substrates or components of ubiquitin ligase E3. Therefore, the neddylation modification process is similar to ubiquitination, which plays a crucial role in the regulation of cell growth, metabolism, and gene expression. This review focuses on the relationship between the neddylation modification process, and tumor signaling pathways, and the tumor microenvironment, as well as the related research progress by targeting neddylation pathways in cancer therapies.
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