Functions of Skeletal Muscle-Derived Exosomes and Its Modulation in Exercise
ZHUANG Shuzhao, XIAO Weihua*
Skeletal muscle-derived exosomes contain various proteins and RNAs, which can not only modulate the proliferation, differentiation and regeneration of skeletal muscle, but also orchestrate the functions of other cell types such as nerve cells, cardiac muscle cells, endothelial cells, osteoblasts, etc. Skeletal muscle-derived exosomes participate in inter-tissue communication through the release of myokines and exerkines, which may be implicated in the exercise-mediated health benefits. In this review, the components and functions of skeletal muscle-derived exosomes and their effects of regulation during exercise are summarized, providing a reference for their development and application in the field of biomedicine and sport science.
CN
EN