Research Progress of Androgen/AR Signaling Pathway in Benign Prostatic Hyperplasia
LIU Nian, LIU Xiangyun*
BPH (benign prostatic hyperplasia) is a common disease in elderly male, which leads to lower urinary tract syndrome and seriously affects the quality of life in elderly male. Androgen and AR (androgen receptor) are essential for the development and growth of prostate. Studies show that AR plays an important role in BPH. AR is activated by dihydrotestosterone, which is involved in regulating the expression of downstream transcription factors, thus causing abnormal proliferation of prostate cells. This paper reviews the function of androgen/AR signaling pathway, androgen and AR in BPH and their possible mechanisms, and introduces the role of pathway related regulatory factors in BPH regulation.
CN
EN