Advances on Reverse Cholesterol Transport in Atherosclerosis
WANG Jiabin, XIAO Yunfei, WU Jun, HAN Mei﹡
RCT (reverse cholesterol transport) is a multi-step process, by which peripheral cell cholesterol can be returned to the liver for catabolism by HDL (high density lipoprotein) via the plasma compartment, and it is an essential mechanism to maintain the lipid homeostasis of peripheral tissue cells. The dysfunction of individual genes relavant to RCT may result in lipid deposition, chronic inflammation and foam cell formation in atherosclerosis, and modulation of RCT serves as a valuable therapeutic strategy for atherosclerotic diseases. This article reviews the latest advances in study on regulation and quantification of RCT in atherosclerosis.
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