Research Progress on the Effect of Tributyltin on Cell Metabolism

ZHAO Xiaoyu¹, ZHU Qiong², YUN Zhaohui¹, WANG Xiaorong¹, JI Lindan^3,4*, XU Jin^1,4*

(¹Department of Preventive Medicine, Medical School of Ningbo University, Ningbo 315211, China; ²Department of Pediatrics, Yinzhou Hospital, Medical School of Ningbo University, Ningbo 315040, China; ³Department of Biochemistry and Molecular Biology, Medical School of Ningbo University, Ningbo 315211, China; ⁴Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China)

Abstract:

Obesity is a risk factor for many cardiovascular, cerebrovascular, and metabolic diseases. With the rapid increase of obesity in recent years it has been one of the critical public health issues in the world. In addition to genetic factors, excessive energy intake, lack of exercise and other factors, many environmental endocrine disruptors may also play important roles in obesity. Among these environmental endocrine disruptors, tributyltin is one of the earliest known compounds belonging to the category of obesogen, since it can cause obesity by promoting fat accumulation and interfering with hormone secretion. This review summarizes the recent studies on the mechanisms of tributyltin interferes with cellular metabolism and promotes obesity.

CSTR: 32200.14.cjcb.2020.09.0018