The Functionary Mechanism of the Meiotic Cohesin RAD21L
MEI Rong*, WUYUN Dalai
Meiosis is a highly specialized program of eukaryotic cell division for sexual reproduction process. During meiosis, two successive meiotic divisions occur after DNA replication, and the number of chromosomes in daughter cells is halved. In order to ensure successful chromosome segregation during meiosis I, the association between homologous chromosomes must be established by the meiosis-specific chromosome movements such as homologous chromosome paring, synapsis, and recombination. Failures in these events will lead to congenital disease or infertility. Hence understanding of the mechanism underlying these unique chromosome behavior in meiosis is of great importance. This review focuses on the specific roles of meiotic cohesin RAD21L and its regulation in chromosome movements during mammalian meiosis.
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