Research Advances in the Function of Claudin-1

JI Rong¹, ZHU Xiaojuan¹, GUO Hailian¹, YIN Leimiao^2*, HUANG Liqiang^1*

(¹Department of Acupuncture, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang 215600, China; ²Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

Abstract:

Claudin-1 is one of the main components of tight junctions. It is located in the region of human chromosome 3q28. It has a molecular weight of 22.7 kDa and is composed of 211 amino acids. Claudin-1 expresses in intestine, esophagus, lung and other tissues, especially in liver, kidney, and skin. It is mainly located in the cell membrane, nucleus, cytoplasm, and the tight junction between two cells. Claudin-1 is one of the important proteins that induces the occurrence of EMT (epithelial-mesenchymal transition), which is involved in tumor cell migration and invasion and mediates anti-apoptosis and cell proliferation. It plays an important role in the occurrence and development of inflammatory bowel disease, tumors, and asthma. Therefore, this article reviews the molecular biological characteristics, tissue expression and subcellular localization, important biological processes and diseases correlated with claudin-1.

CSTR: 32200.14.cjcb.2020.09.0014