Home > Browse Issues > Vol.42 No.9
Roles of Dopamine Receptor D2 Signaling in Tumorigenesis and Treatment
LIU Yumei, AN Shu, LIU Ying, HAO Qian, GUO Xiaoxi, XIANG Cheng, XU Tianrui*, YANG Yang*
(Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China)
Abstract:
Dopamine receptor D2 is a member of the G protein-coupled receptor family. D2 signaling pathway, an important drug target, is involved in the regulation of cell secretion and cell viability. Current studies have shown that D2 is widely expressed in many tumor cells and has important significance to the genesis, development and metastasis of tumor. This review will summarize the role of D2 in tumorigenesis and treatment, as well as the D2 distribution, signal transduction, and selective ligands in different tumors.
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