Expression and Function of Mechanosensitive Ion Channel Piezo in the Gastrointestinal Tract
YU Tianzhuo, GAO Ruitong, LI Feng*
Piezo is a new class of mechanosensitive channel proteins that can sense changes in cell membrane mechanical forces and is critical to cell mechanical sensitivity. Intestinal epithelial chromaffin cells, intestinal smooth muscle cells, and Cajal interstitial cells can all respond to mechanical forces through mechanically sensitive ion channels, affecting the gastrointestinal physiological functions. This article introduces the expression and function of Piezo in tissues and organs, focuses on the expression and function of Piezo in various tissues of the gastrointestinal tract, and discusses the effect and influence of Piezo on the gastrointestinal tract under physiological and pathological conditions.
CN
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