Differences of Glucose and Lipid Metabolisms between the Myogenic Differentiation and the Adipogenic Trans-Differentiation in C2C12 Cells
QIU Xiaoyu1#, HAN Xu2#, QI Renli1,3*, WANG Jing1, WANG Qi1, WU Min1
Myoblasts could transdifferentiate into adipocytes or adipocyte-like cells with the capability for producing and storing intracellular lipids. This present study compared the difference in glucose and lipid metabolism in the normal myogenic differentiated and the adipogenic trans-differentiated C2C12 myoblasts. Results showed that the uptake, transport, metabolism of glucose and energy utilization were more active in the myogenic differentiated cells, while the adipogenic differentiated cells had higher intensity in lipid absorption, transport, and synthesis metabolism. These findings indicated that the cellular metabolism had undergone significant change during the lipogenic conversion process in muscle cells that was closely related to the changes of structure, functions and molecular characteristics of the cells.
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