Research Advances of Cell Envelope Stress Response in Bacteria

WANG Chuhan¹, YUAN Lin^1,2, WU Hao¹, QIAO Jianjun^1,3*

(¹Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; ²College of Food Science and Bioengineering, Tianjin Agricultural University, Tianjin 300384, China; ³Syn BioResearch Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, China)

Abstract:

Cell envelope is the first barrier for bacteria to monitor the environmental changes and respond in time. It plays a role in protecting cells from the stresses of temperature, pH, osmotic pressure, metal ions, reactive oxygen, and antibiotics. CESR (cell envelope stress response) senses envelope damage and alters the transcription to mitigate stress. Two-component system and ECF (extra-cytoplasmic function) sigma factor are the main CESR. Moreover, more and more studies have found that non-coding small RNA can synergistically regulate CESR. However, due to the differences in envelope structures between Gram-negative and Gram-positive bacteria, the respective response mechanisms are also different. Here, according to the structures of the cell envelope, the advances in CESR from two aspects of Gram-negative and Gram-positive bacteria in detail are reviewed, as well as the research direction of CESR in the future is prospected.

CSTR: 32200.14.cjcb.2020.08.0022