Research Progress of Mitochondria-Associated Endoplasmic Reticulum Membrane in Neurodegenerative Disorders

ZHOU Juanping¹, SU Gang², CHEN Lixia¹, WANG Manxia¹, TIAN Ye¹, ZHANG Jiajia¹, GAO Juan¹, ZHANG Zhenchang¹*

(¹Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730030, China;²Institute of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China)

Abstract:

MAM (mitochondria-associated endoplasmic reticulum membrane) is a special region in close contact between the outer mitochondrial membrane and the endoplasmic reticulum membrane, which is involved in the regulation of Ca2+ homeostasis, lipid synthesis and transfer, mitochondrial fission and fusion, endoplasmic reticulum stress, autophagosome formation, apoptosis, and the formation of inflammatory bodies. In recent years, more and more studies have found that structural and functional abnormalities of MAM are closely related to the pathogenesis of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. This review focuses on the structure and function of MAM and its role in neurodegenerative diseases to provide a theoretical basis for exploring the therapeutic targets of neurodegenerative disorders.

CSTR: 32200.14.cjcb.2020.08.0020