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Function and Regulation of M2 Isoform of Pyruvate Kinase
CAO Shanhu, HE Jiali, DONG Lihua*
(Department of Biochemistry and Molecular Biology, College of Basic Medicine, Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang, 050017, China)
Abstract:
Glycolysis is the rapid way to provide energy and aerobic glycolysis is the main way of tumor metabolism. PK (pyruvate kinase) is the rate-limiting enzyme of the glycolytic pathway, of which PKM2 (M2 isoform of PK) distributes extensively and has the most important function. It can be transported into mitochondria to affect cell survival and can regulate gene expression after entering the nucleus. It can be used as an indicator for tumor diagnosis, a target for treatment and a reference for prognosis. Understanding of the function of PKM2 and its regulatory mechanisms can provide new ideas for the diagnosis and treatment of diseases.
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