Neural Stem Cell-Derived Exosomes—a New Approach for the Treatment of Neurological Diseases
ZHAO Shumei, CHEN Yanying, AI Zongyong, NIU Baohua, CAI Hongzhi*
Exosomes are released by nearly all cell types and carry a cargo of proteins, nucleic acids and lipids that vary by the origin of cell. Exosomes participate in the communication of information between cells. Recent studies have shown that NSC (neural stem cell)-derived exosomes can participate in the physiological and pathological changes of neurological diseases and play their potential neuroregulatory and repair functions. Thus, NSC-derived exosomes can also afford therapeutic benefits. First, this review describes the biosynthesis of exosomes. Then, the properties and functions of NSC-derived exosomes and advances in the treatment of neurological diseases are summarized. Finally, the potential and challenges of exosomes in the treatment of neurological diseases are discussed.
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EN