Human Pluripotent Stem Cell-Derived Spinal Cord Motor Neuron: from Developmental Biology to Therapeutic Applications

DONG Siqi¹, XU He², JING Naihe^2,3,4*, CHEN Xiangjun¹*

(¹Department of Neurology, Huashan Hospital, Fudan University, Institute of Neurology, Fudan University, Shanghai 200040, China;²Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, State Key Laboratory of Cell Biology, Shanghai 200031, China;³Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China;⁴Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China)

Abstract:

hPSC (human pluripotent stem cell) includes ESC (embryonic stem cell) and iPSC (induced pluripotent stem cell), having the potential to differentiate into a variety of human cell types. In recent years, there has been some progress in the study of its in vitro differentiation into spinal anterior horn motor neurons. In this perspective, the state of the field in generating spinal cord motor neuron from hPSCs were reviewed based on our fundamental understanding of neurodevelopment. Then, their applications for studying human neurodevelopment, modeling disease and cell replacement therapy were highlighted.

CSTR: 32200.14.cjcb.2020.08.0012