The Role of Hippo Pathway in Ferroptosis
KANG Chenlu, REN Xiaoyu, WU Congying*
Hippo pathway, which plays a critical role in cell growth, survival, proliferation, migration, or-gan size control and tumorigenesis, is primarily composed of two Serine/Threonine kinases, MST1/2 and LATS1/2, and the transcriptional coactivator YAP. Ferroptosis, triggered by the impairment of oxidant-antioxidant system, is an iron-dependent mode of regulated cell death characterized by the accumulation of ROS (reactive oxygen spe-cies) and plasma membrane PUFAs (polyunsaturated fatty acids) peroxidation. This paper makes a comprehensive overview of the correlation between Hippo pathway and cell death, especially ferroptosis, providing ideas for cell fate regulation and tumor treatment.
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