MicroRNAs Regulate Hepatic Insulin Resistance by Regulating Hepatic Glycolipid Metabolism
WEI Hongzhan, ZHONG Lianchao, GAO Binghong*
The balance and stability of liver glucose and lipid metabolism are of great significance to liver insu-lin resistance. MicroRNAs can regulate liver glucose and lipid metabolism, thereby regulating liver insulin resistance. Mi-croRNA-33a, microRNA-33b, microRNA-122, microRNA-34a, microRNA-148a-3p and microRNA-676 can promote lipid synthesis, inhibit lipid breakdown, cause liver lipid accumulation and induce liver insulin resistance. MicroRNA-223 and microRNA-30c can promote lipid breakdown, inhibit lipid synthesis, reduce liver lipid accumulation, and improve liver insulin resistance. Lethal factor-7, microRNA-29, microRNA-423-5p, microRNA-802 and microRNA-155 can in-hibit the insulin signaling pathway, thereby inhibiting liver glucose uptake, promoting liver gluconeogenesis and causing liver insulin resistance. MicroRNA-26a and microRNA-451 can inhibit liver gluconeogenesis and improve liver insulin resistance. In this article, by studying the mechanism of microRNAs regulation of liver glucose and lipid metabolism, the mechanism of microRNAs regulation of liver insulin resistance was elucidated, deepening people’s understanding of mi-croRNAs, and providing valuable clues for the treatment of type 2 diabetes.
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