Research Progress in the Structure and Function of SEDS Protein

LI Chenchen^1,2,3 WU Hao^1,2,3 TIAN Kairen^1,2,3 QIAO Jianjun^1,2,3 LI Yanni^1,2*

(¹Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; ²Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China; ³Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China)

Abstract:

Peptidoglycan is the main component of bacterial cell wall and plays an important role in maintaining cell viability, shape and protecting osmotic pressure. SEDS protein is a family of membrane proteins involved in peptidoglycan synthesis. Its members are related to cell shape, elongation, division and spore formation. A series of genetic and biochemical evidences show that SEDS protein has glycosyltransferase function and is the core polymerase of cell elongation and division mechanism. Considering its extensive distribution, conservative structure and critical function, SEDS protein is expected to be an essential target for the development of new antibiotics. The structure and function of SEDS protein are summarized. Its structure characteristics and regulation mechanism in peptidoglycan synthesis are highlighted. In the end, the application and development of SEDS protein are prospected.

CSTR: 32200.14.cjcb.2020.06.0013