Pulmonary Surfactant and Related Respiratory Diseases
WANG Linfang, HU Xuefeng*
Pulmonary surfactants are lipid protein complexes produced by alveolar type II epithelial cells, cover the gas-liquid exchange interface in the alveolar region. They are maintaining the surface tension of the lungs to prevent alveoli against excessive expansion/collapse, maintaining normal alveolar morphology and performing host defense. Defects in pulmonary surfactant may cause a variety of respiratory diseases, including respiratory distress syndrome, interstitial pneumonia, meconium aspiration syndrome, pulmonary fibrosis, and alveolar proteinosis. This article reviews the composition, anabolism and function of pulmonary surfactants, as well as the relationship between pulmonary surfactant deficiency and respiratory diseases, and provides a theoretical basis for respiratory diseases caused by pulmonary surfactant deficiency.
CN
EN