Molecular Structure and Biological Functions of DOCK8

HUANG Jingxiong¹, GUAN Xiaoyan¹*, YU Hongsong³, HU Huan², LIU Jianguo^1,2*

(¹School of Stomatology, Zunyi Medical University, Zunyi 563099, China; ²Key Laboratory of Oral Disease Research and Key Laboratory of Oral Disease Research, Guizhou University, Zunyi 563006, China; ³Department of Immunology, School of Basic Medical Sciences, Zunyi Medical University, Zunyi 563006, China)

Abstract:

DOCK8 (dedicator of cytokinesis 8) is an atypical GEF (guanine nucleotide exchange factor) involved in the regulation of intracellular signaling networks and activation of small molecule G proteins. Due to the key role playing in the signal transduction of immune response, reconstruction of actin skeleton, formation of immune synapse, and regulation of immune cells, DOCK8 has become a research hotspot. The advance in the molecular structure and biological characteristics research of DOCK8 were reviewed in this paper, and the biological function of DOCK8 in immune system and pathogenesis of the disease were further clarified.

CSTR: 32200.14.cjcb.2020.04.0017