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The Application of RNA Interference to Protozoa
Hong Zeng1,2, Jie Shen1, Fu-Kang Gu1*
1School of Life Sciences, East China Normal University, Shanghai 200062, China;2College of Life Sciences, Fujian Normal University, Fuzhou 350007, China
Abstract: RNA interference (RNAi)， triggered by double stranded RNA (dsRNA)， was the post-transcriptional gene silencing (PTGS) based on sequence-specific degradation of mRNA. It had been proved to be an efficient method for analyzing gene functions in protozoa. In this paper， we reviewed the RNAi methods and their main research progress in cell and molecular biology of protozoa which focused on the assembly of base body and functions of tubulins， cyclins and telomerase， gene rearrangement and exocytosis of the trichocyst of the ciliated protozoa.
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