Mechanisms of Non-Typeable Haemophilus influenzae Infection and Drug Resistance
MA Yushuai, CHEN Rui, ZHAO Ying, ZHANG Yutuo*
NTHi (non-typeable Haemophilus influenzae), as a major pathogen that causes enormous global morbidity in two clinical diseases—otitis media in children and acute exacerbations with chronic obstructive pulmonary disease in adults, has been increasingly focused by scholars at home and abroad. However, the mechanisms associated with NTHi infection and drug resistance has not been fully expounded so far, which affects the clinical control of NTHi infection to some extent. This article comprehensively analyzes the main infections caused by NTHi, and reviews the mechanisms and drug resistance of NTHi infection from four aspects—colonization strategy based on adhesion, biofilm formation, immune escape, and bacterial resistance, to provide a theoretical basis for the study of effective vaccines and specific anti-infective drugs of NTHi.
CN
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