Advances in the Research of Spermatogonial Stem Cell Techniques
ZHU Wenqian, JIANG Yu, CAI Ningning, YANG Rui, ZHANG Xueming*
SSCs (spermatogonial stem cells) are the most primitive spermatogonial cells located on the basement membrane of the seminiferous tubules in the testis, which can self-renew and differentiate continuously to produce sperm. SSCs are the only replicable diploid cells which can transfer genetic information into offspring naturally in male body throughout life. They play an important role in the complex spermatogenesis process. As an undifferentiated cell population, SSCs have the role of gene transfer necessary for the generation of male gametes and species evolution. Based on our previous research, the biological characteristics, isolation and enrichment, factors affecting in vitro culture and transplantation technology of SSCs are systematically reviewed, which has theoretical significance for the research and application of male assisted reproduction, cell regeneration therapy as well as animal husbandry production.
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