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Progress in Checkpoint Kinase 1
Chang-Jun Li, Kai-Yu Liu, Dong-Ye Yang, Ze-Hua Yu , Jian-Xin Peng*, Wen Chen, Fei Xie
Institute of Entomology, Central China Normal University, Wuhan 430079, China
Abstract: Checkpoint kinase 1 (Chk1)， an evolutionarily conserved protein kinase， is an effector of cell DNA damage checkpoint. When DNA was damaged or DNA replication fork halted by ionization radiation or ultraviolet radiation， Chk1 was activated， which induced cell cycle arrest， DNA repair or cell apoptosis. In this review， we described the structure and function of Chk1 and discussed how the virus regulate the cell cycle of host cell by manipulating Chk1.
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