Research Progress of Notch Signaling Pathway in Angiogenesis of Bone Microenvironment

ZHANG Shihua¹, YUAN Yu², ZOU Jun^1*

(¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; ²School of Physical Education and Sports Science, South China Normal University, Guangzhou 510631, China)

Abstract:

The blood vessels in the bone are highly distributed, and the bone vessels provide the necessary nutrients for the development, regeneration and repair of the bone, maintaining the balance of the bone microenvironment and bone metabolism. Recent studies have shown that the decline in bone microenvironmental angiogenesis caused by aging is one of the key factors inducing osteoporosis. Among them, Notch signaling pathway plays an important role in the regulation of angiogenesis, but there are relatively few reports on the regulation of bone microenvironment angiogenesis by Notch signaling pathway. In view of this, this paper mainly reviews the mechanism of Notch signaling pathway in bone microenvironment angiogenesis, providing a theoretical basis for the study of the mechanism of bone angiogenesis.

CSTR: 32200.14.cjcb.2019.12.0021