Research Progress of Mesenchymal Stem Cell-Derived Exosomes in Repair of Urinary System Injury

AO Ping^1,2, SHU Ling³, ZHUO Dong¹, XU Jie², ZHOU Yiduo², WEI Zhongqin^2*

(¹Department of Urology, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, China; ²Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China; ³Department of Operating Room, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, China)

Abstract:

MSC-Exos (mesenchymal stem cell-derived exosomes), as a new method for the treatment of urinary system injury, has become one of the research focuses in stem cell and regenerative medicine technology. Exosomes have the advantages of lower immunogenicity, lower risk of infection and tumorigenesis in cell transplantation, and more stable biological characteristics as paracrine products compared with stem cells. MSC-Exos from different tissue sources show a certain repair capacity in urinary system injury. This paper reviewed the literatures about the application of MSC-Exos on urinary system injury in recent years to provide a further basis for the mechanism and related research.

CSTR: 32200.14.cjcb.2019.12.0015