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The Structure and Function of Protein Interacting with C a Kinase
Hong Xiao, Jing-Ming Yuan, Ya-Wei Shi*
Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, China
Abstract: Protein interacting with C a kinase (PICK1) contains a single PDZ domain known to mediate the interaction with several receptors， transporters， ion channels and kinases， and a BAR domain interacted with other proteins and membrane besides PDZ domain itself， as well as a coiled-coil and an acidic amino acid regions. PICK1， as an adaptor protein between protein kinase C a (PKCa) and receptors at synapse performs its biological function through the interaction with different partners in synaptic plasticity， neurotransmitter regulation， peripheral nervous sensory， cell-cell adhesion and cell growth. In this review， we focus on the structure and function of PICK1.
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