Progress in Axin

Abstract: As a multifunctional scaffold protein， Axin participates in many kinds of physiological and pathological processes， including embryo development， carcinogenesis， cell apoptosis and glycogen metabolism etc.， and plays important roles at least in Wnt signaling pathway， SAPK signaling pathway， TGFb signaling pathway and insulin signaling pathway. The investigation of Axin will be help to figure out the important biological problems such as embryo development and carcinogenesis， and provide new insights into the signaling transduction and its regulatory net. This review is to focus on recent developments of the effects of Axin on diseases， metabolism and especially on cell signaling transduction pathway.
    

CSTR: 32200.14.cjcb.2006.02.0003