New Mechanism of Chemerin and Its Receptor CMKLR1 in the Development of Obesity
ZHANG Qilong, WANG Xiaohui*
As an adipokine and an inflammatory factor, chemerin exerts important roles in occurrence and progression of obesity through the mediation of its receptor CMKLR1, and chemerin/CMKLR1 may be the most promising therapeutic target for obesity and obesity-related diseases. The underlying mechanisms by which chemerin/CMKLR1 influence the development of obesity have been demonstrated to be closely related to the regulations in inflammation and glycolipid metabolism. In recent years, some new mechanisms of chemerin/CMKLR1 in the occurrence and progression of obesity have been reported, involving in multiply modulation in adipose tissue (including differentiation of mesenchymal stem cells to adipocytes, and angiogenesis and thermogenesis of adipose tissue), and regulations in gut microbiota composition, androgen secretion and appetite. In addition, although most of the literatures support a positive correlation between chemerin/CMKLR1 and obesity, there are different even opposite reports. This review focuses on the new mechanisms of chemerin/CMKLR1 in the development of obesity, and the possible reasons for the discrepancy among reports.
CN
EN