Advances in Stem Cell Transplantation for the Treatment of Inflammatory Bowel Disease

ZHAO Linlin^1,2, LIANG Rui³, WANG Zhiqiang⁴, SUN Yi²^*

(¹Medical Faculty, Kunming University of Science and Technology, Kunming 650500, China; ²Department of Clinical Laboratory, the First People’s Hospital of Yunnan Province, Kunming 650032, China; ³Department of Pathology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China; ⁴Department of General Surgery, the Second Hospital of Tianjin Medical University, Tianjin 300211, China)

Abstract:

Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, has a prolonged course of disease, serious complications, can cause serious digestive dysfunction, and even endangers the life of patients. It is a major medical problem in clinical treatment today. Traditional medicines and treatments are not effective in treating inflammatory bowel disease and can lead to drug dependence and adverse reactions. The study found that stem cell transplantation can repair intestinal damage and restore the intestinal immune system, bringing new hope to the cure of inflammatory bowel disease. In this paper, the research progress of various stem cell transplantation such as hematopoietic stem cells, mesenchymal stem cells, intestinal stem cells, induced pluripotent stem cells and parthenogenetic embryonic stem cells for the treatment of inflammatory bowel disease is reviewed.

CSTR: 32200.14.cjcb.2019.11.0019