The Role of Irisin in Metabolic Cardiovascular Disease by Regulating the Function of Endothelial Cell
XIE Jinfeng1, LIANG Jiling1, FENG Ziyuan1, CHEN Ning2*, JIA Shaohu2*
Vascular endothelial cells dysfunction such as inflammation, apoptosis, oxidative stress and nitrification stress of endothelial cells is highly correlated with metabolic cardiovascular diseases. Irisin as a newly discovered myokine is closely related to glucose and lipid metabolism. In recent years, irisin has been widely concerned in the prevention and treatment of diabetes through regulating lipid metabolism. Meanwhile, the role of irisin in metabolic cardiovascular diseases has also gained extensive attention, but the regulatory role and underlying mechanism of irisin in metabolic cardiovascular diseases is not clear. In the review, we summarize the origin and function of irisin, and also investigate it’s role and the underlying mechanism in metabolic cardiovascular diseases by regulating the founction of endothelial cell, including the activation of diastolic vascular signaling pathway, the inhibition of oxidative stress pathway in vascular endothelial cells, the decrease of inflammatory signaling pathway in vascular endothelial cells and the promotion of the proliferation and migration of vascular endothelial cells, and so on. Finally, the prospects of irisin in clinical application have also been proposed.
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