Physiological Function of Ca2+ Binding Protein Rcn2
FAN Peng, AN Shu, YANG Yang, LIU Ying, XU Tianrui*, GUO Xiaoxi*
Rcn2 (Reticulocalbin2), a secreted protein ubiquitous in mammalian cells, is not only necessary for cells to maintain normal physiological functions, but also participates in tumor cell growth, invasion, and susceptibility genes to atherosclerosis, papillomavirus binding protein E6, serine/threonine kinase 40, vitamin D receptor and other biomolecules interact in atherosclerosis, cervical cancer, vitamin D absorption abnormalities, etc. It plays an important role in disease control. This article summarizes the latest research on the effects of Rcn2 on the human papilloma virus, Taipoxin snake venom intake synapse mechanism, SOC calcium channel, EGFR-ERK signaling pathway, ERK-MAPK signaling pathway, and molecular mechanism, etc. The important functions of Rcn2 and its interacting molecules were summarized, which provided important scientific basis for the diagnosis and treatment of diseases such as colorectal cancer, liver cancer and atherosclerosis.
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