Antimicrobial Peptides: An Emerging Category for Cancer Treatment
LÜ Yudie1, SHAO Gang1, MENG Yueming2, JIN Yuanting1*, FU Caiyun2*
Antimicrobial peptides (AMPs) are small molecular peptides that are induced by organisms. Most AMPs play an anti-microbial and immunomodulatory role in the body. The antimicrobial mechanism of AMPs is mainly through cell membrane perforation and physiological processes that target intracellular cells. AMPs have functions in immunomodulatory including pro-inflammatory and anti-inflammatory, skin barriers and maintenance of the homeostasis of the organism. In recent years, the role of AMPs in the development of various cancers has also made great progress. AMPs play an important role in promoting or inhibiting proliferation of cancer cells through multiple signaling pathways in the microenvironment. In this review, we provided a conspectus of the classification and biological roles of AMPs, especially on cancer treatment, in order to provide new therapeutic targets and ideas for cancer therapy.
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