Advances in Research on Effect of PGC-1α in Tumors
YANG Hao, WANG Xinyue, LUO Ying, JIA Shuting*
The peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α)is an important regulator of diverse metabolic pathways, such as oxidative metabolism and energy homeostasis. It is also involved in regulating mitochondrial biogenesis and function. Given the altered and highly adaptable metabolism of tumor cells, it is very important to study the role of PGC-1α in tumor. Although the expression and clinical research of PGC-1α in cancer are many, there are still many controversies about the role of PGC-1α in cancer. This article will review the latest research data of PGC-1α in cancer, and provide more reference for further understanding the relationship between PGC-1α and cancer.
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