Mechanisms of Calcium Sensing Receptor Regulation on Tumorigenesis and Development
WU Shiyong, MA Shumin, YI Ping* , LIU Jianfeng*
As a widely-expressed transmembrane receptor, calcium sensing receptor (CaSR) plays an important role in maintaining body calcium homeostasis by regulating parathyroid hormone secretion. In addition, CaSR is implicated in various physiological and pathological processes. Increasing evidences indicate that CaSR is closely related to tumor progression. Due to the functional diversity and tissue specificity, CaSR may function as either tumor promoter or tumor suppressor in different types of tumors. CaSR acts as a tumor promoter in prostate cancer and renal cell carcinoma. While in colon cancer, neuroblastoma and parathyroid carcinoma, CaSR is a tumor suppressor. Studies on the role of CaSR in different tumors are beneficial to research and development of new anti-tumor drugs, as well as tumor therapy targeting CaSR. Herein, we summarized the function and underlying mechanism of CaSR in different types of tumors, aiming to provide theoretical basis for future research.
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