Review of Industrialized Production Technology of Human Inactivated Vaccine Based on Mammalian Cell Culture
BAI Zhonghu1, LI Xinran1, WANG Rongbin1, LIU Xuerong2, AN Fanglan2, ZHANG Yunde2, LIU Xiuxia1, LIU Chunli1, YANG Yankun1*
Vaccine has been recognized as the principal method of preventing many diseases for its superiority, such as easy to vaccinate, high efficiency, less side effects, etc. People’s increasing awareness on importance of epidemic prevention leads to elevate demand for vaccines, which requires larger capacity and lower cost of vaccine industrial production. Meanwhile, the large demand makes drug supervision organizations pay more attention to the quality of vaccines. Based on the situation, the review summed up the development of vaccines production technology, analyzed the current situation of cell culture and quality control strategy of vaccines production, and put forward the developing direction of production technologies for human inactivated vaccine.
CN
EN