Molecular Regulation Mechanism of Hepatic Lineage Differentiation and Maturation
YANG Li1,2, Lamaoqiezhong1,2, XU Cheng-Ran1*
The liver is an important organ for metabolic regulation and drug detoxification that performs a variety of physiological functions in the body. Liver diseases have increasingly affected human health and quality of life. Considering urgent needs for clinical research and translational medicine, we must thoroughly define the differentiation and maturation processes and molecular regulatory mechanisms of liver cells, especially hepatocytes and cholangiocytes. This article outlines the differentiation and maturation processes of endoderm derived hepatic lineages, summarizes the signaling pathways and transcription factors involved in these developmental processes, and briefly introduces the promotion of advanced technologies for liver development research. These achievements guide us to efficiently induce or establish more mature liver-like cells or organoids in vitro for liver disease-related research and treatment.
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