The Research Progress of Mechanosensitive Ion Channel Protein Piezo1 on Regulating Chondrocytes Apoptosis

Chondrocytes experience a complex mechanical environment and respond to changing mechanical loads sensitively and accurately in order to maintain cartilage homeostasis. If mechanotransduction pathways are disrupted, the cartilage may become damaged, which can result in osteoarthritis and other painful joint diseases. Mechanically gated ion channels are of functional importance in chondrocyte mechanotransduction. Some studies showed that the Piezo1-mediated mechanotransduction pathway modulates mechanical load-mediated chondrocyte injury, protecting articular chondrocytes from mechanically induced cell death. In this paper, we summarized the regulation of Piezo1 on chondrocytes apoptosis under mechanical stress stimulation by reviewing the literature on Piezo1 protein and chondrocytes,which can provide a basis for the treatment of chondrocyte-related diseases such as osteoarthritis.

CSTR: 32200.14.cjcb.2019.09.0019