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Advances in Researches of Molecular Mechanisms of Nicotine Affecting Metabolisms
LEI Zili1, CHI Zuohua2, YANG Yanhong2*
(1Institute of Chinese Medicinal Sciences, Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China; 2The First Affiliated Hospital/School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510080, China)
Abstract:
Smoking can cause disorders of glucose and lipid metabolism, and lead to insulin resistance. Smoking cessation can increase body weight, but the molecular mechanisms of smoking affecting metabolism is still unclear. In this review, the molecular mechanisms of nicotine affecting metabolism through AMPK signaling pathway, inflammation and apoptosis-related signaling pathways were summarized and discussed, which would provide scientific basis for further research on the role of nicotine in the prevention and treatment of metabolic diseases in the future.
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