The Role of Astrocyte Reprogramming in Brain Injury
LI Xin, DU Yao, RAN Li, ZHOU Ningna*
The neuron death and apoptosis after brain injury lead to limb, language and cognitive dysfunction. Therefore, it is critical to repair neuron after brain injury. Recent research shows that astrocyte can be converted into neuron through reprogramming, including dedifferentiation and trans-differentiation, which opens a new avenue for neuron repair. The dedifferentiation induces astrocytes to form neurosphere in vitro but cannot develop into functional neurons after being transplanted in vivo. Trans-differentiation includes direct trans-differentiation and indirect lineage reprogramming. While the indirect lineage reprogramming needs very long time to generate neurons and have the risk of tumorgenesis, in vivo direct trans-differentiation could be the safe and effective method to induce neurogenesis. This article reviewed the role of astrocyte or reactive astrocyte reprogramming in neurorepair.
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