The Research Progress of Autophagy in Mycobacterium tuberculosis Infection

MA Qinmei¹^,2, HAN Lu¹^,2, DENG Guangcun¹^,2, WU Xiaoling¹^,2*

(¹Department of Nephrology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 53300, China; ²Science Lab Center, Youjiang Medical University for Nationalities, Baise 533000, China)

Abstract:

The infection of Mycobacterium tuberculosis (Mtb) is the cause of tuberculosis (TB), which remains a fatal rate in most parts of the world. The mechanism of the interaction between Mtb and host cell is complicated and unclear. Moreover, the fate of Mtb and macrophage are related with autophagy. In this context, we summarize current knowledge about the role of autophagy in Mtb infection. By mostly morphological and mechanically studies, it showed that autophagy can effectively suppress Mtb infection to macrophage. Oppositely, Mtb break the autophagic process by self-protection. In light of the interaction between autophagy and Mycobacterium tuberculosis, it provides novel insights for studying pathogensis and physiological control of tuberculosis.

CSTR: 32200.14.cjcb.2019.09.0015