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Signal Transduction and Cell Origin During Liver Regeneration
CHEN Feng, PENG Jinrong*
(MOE Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China)
Abstract:
Liver is the only mammalian internal organ capable of regrowing to 100% of its original weight after partial hepatectomy, which makes it an ideal model for organ regeneration research. There has been a long history of researches on signal transduction and transcriptional regulation during the process of liver regeneration, especially after partial hepatectomy. In this review, the current understanding of the signaling pathways and cell origins governing liver regeneration based on the latest studies in mouse and zebrafish models are summarized.
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