Recent Advances on Cardiac Proliferation and Regeneration in Model Organisms
PANG Meijun, ZHU Xiaojun*, XIONG Jingwei
Ischemic cardiomyopathy post myocardial infarction has become a major threat to human health. Unlike adult mammals, some fish, amphibians and newborn mammals can achieve perfect regeneration after cardiac injury due to their capacity of cardiomyocyte proliferation. Thus promoting cardiomyocyte proliferation has become a promising therapeutic strategy for ischemic cardiomyopathy. Here, we present a brief review on cardiac regeneration models in animals, and the key cellular and molecular mechanisms on cardiomyocyte proliferation and regeneration. Finally, we summarize and speculate future research directions to provide concise literature reference for both basic and clinical research scientists in the field of cardiac regenerative medicine.
CN
EN